The FINANCIAL — New sub-analysis data presented on November 9 showed the reduction in risk for hospitalization for heart failure or cardiovascular death with Jardiance (empagliflozin) compared with placebo when added to standard of care in patients with type 2 diabetes (T2D) at high risk of cardiovascular (CV) events was consistent across all sub-groups analyzed, including those who had heart failure at baseline and those who did not.
These results were presented on behalf of Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) and Eli Lilly and Company (NYSE: LLY) at the 2015 Scientific Sessions of the American Heart Association in Orlando, Fla. The data were part of a pre-specified analysis of secondary endpoints of the landmark EMPA-REG OUTCOME trial, according to Lilly.
“Cardiovascular disease, including heart failure, is the leading cause of death associated with diabetes,” said Silvio Inzucchi, M.D., professor of medicine, Yale School of Medicine. “People with diabetes are two- to three-times more likely to develop heart failure than those individuals without diabetes. We need treatments that can help reduce the high rates of heart failure—and the resulting hospitalizations and deaths—in this population.”
New data also presented today demonstrate JARDIANCE reduced the risk of the composite endpoint of rates of hospitalization for heart failure or death from heart failure by 39 percent compared with placebo when added to standard of care in patients with T2D at high risk of CV events.
“To date, no glucose-lowering medication has been shown to reduce the risk of hospitalization for heart failure or death from heart failure in a cardiovascular outcomes study,” said Prof. Hans-Juergen Woerle, global vice president medicine, Boehringer Ingelheim. “These results with JARDIANCE show the importance of continuing to advance research that will help our understanding of how to manage and mitigate the risk of cardiovascular disease in people with type 2 diabetes.”
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