The FINANCIAL — Researchers from the University of Liverpool, in collaboration with Public Health England, have determined why Ebola virus becomes increasingly lethal as it jumps species.
Scientists investigated why Ebola virus is so deadly when it spreads from animals to humans and then from human-to-human contact. The research team looked at the Zaire Ebola strain in an animal system to understand how it gains strength. This virus is responsible for the current outbreak in West Africa. They found that initially the animal systems were not affected by the virus, but subsequent transmission into other animals caused the virus to ‘hot up’ and become more severe, according to the University of Liverpool.
The team analysed the viruses at different stages and were able to identify several changes in its genetic material that were associated with increased disease.
Evolutionary goal
“The work tells us that the evolutionary goal of Ebola virus is to become more lethal,” Professor Julian Hiscox, who led the study from the University’s Institute of Infection and Global Health, said.
“We were able to show through genetic analysis which parts of the virus are involved in this process. The information we have gathered will now allow us to monitor for such changes in an outbreak as well as develop future treatment strategies,” Hiscox added.
“Ebola virus is such a devastating infection to the people affected by the disease and the economy of West Africa,” Professor Roger Hewson, leading the study from Public Health England, Porton Down, said.
“Our understanding of Ebola virus biology is way behind that of other viruses and our collaboration shows how we can bring together our specialists skills to close this knowledge gap,” he added.
“This study has allowed the team to be at the forefront of developing methodologies to analyse patient samples recently taken by the European Mobile Laboratory from West Africa to understand disease evolution during the current outbreak,” Professor Miles Carroll, a co-author of the work, said.
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