Vaccines against 10 diseases prevented 37 million deaths in low- and middle-income countries in the last 20 years

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The FINANCIAL – Vaccine programmes in low- and middle-income countries have prevented 37 million deaths in the last 20 years alone – 36 million of which would have been in children aged under-five, according to new research published last week in The Lancet.

The research is the most comprehensive study of the impact of vaccination programmes ever. It was conducted by the Vaccine Impact Modelling Consortium (VIMC) – a multinational collaboration of 16 research groups, including experts from the London School of Hygiene & Tropical Medicine (LSHTM).

It shows success of vaccination will continue, with a further 32 million deaths predicted to be prevented by vaccination programmes by 2030 (28 million deaths prevented in under-fives), if progress is sustained.

Additionally, the researchers have published an article in the Biomedical Science Journal for Teens to engage the younger generation with the important topic of vaccinations and their potential impact around the world. The teens can then test their knowledge of epidemiology with a pop quiz at the end of the paper.

Infectious diseases are still a major cause of disease and deaths, especially in low- and middle-income countries. Vaccination is one of the most cost-effective health interventions available. Childhood vaccination programmes have increased over the last two decades globally, substantially reducing disease and deaths from diseases such as measles, meningitis and hepatitis. This study offers the most reliable estimates of the impact of childhood vaccinations on mortality yet undertaken.

The VIMC generated estimates from at least two independent models, for each of ten diseases; Hepatitis B, Haemophilus influenzae type b (Hib), human papillomavirus (HPV), Japanese encephalitis, measles, meningitis A (Neisseria meningitidis serogroup A), pneumococcal disease (Streptococcus pneumoniae), rotavirus, rubella, and yellow fever.

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The estimates focused on deaths averted by vaccination from these diseases in 98 low-and middle-income countries, in the period 2000-2030. These countries include over two thirds of the world’s population.

The consortium estimates that vaccinations against the 10 diseases have prevented 37 million deaths between 2000 and 2019, of which 36 million were deaths averted in children under the age of five years.

The study estimated a further 32 million deaths will be prevented by 2030 due to vaccine programmes, of which 28 million are deaths averted in under-5s. During the lifetime of those born in 2019, vaccination was estimated to prevent 72% of the mortality from the 10 diseases. This proportion rises to 76% when just under-five mortality is considered.

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